Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment

We have previously reported that direct injection of dendritic cells (DC) engineered to express the Type-1 transactivator Tbet (i.e., DC.Tbet) into murine tumors results in antitumor efficacy in association with the development of structures resembling tertiary lymphoid organs (TLO) in the tumor mic...

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Bibliographic Details
Main Authors: Aliyah M. Weinstein, Lu Chen, Emily A. Brzana, Prashanti R. Patil, Jennifer L. Taylor, Kellsye L. Fabian, Callen T. Wallace, Sabrina D. Jones, Simon C. Watkins, Binfeng Lu, David F. Stroncek, Timothy L. Denning, Yang-Xin Fu, Peter A. Cohen, Walter J. Storkus
Format: Article
Language:English
Published: Taylor & Francis Group 2017-06-01
Series:OncoImmunology
Subjects:
dendritic cells
immunotherapy
interleukin (il)-36γ
tbet
tertiary lymphoid organ
tumor
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1322238

Internet

http://dx.doi.org/10.1080/2162402X.2017.1322238

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