A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer

A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer

XPD functions in transcription, DNA repair and in cell cycle control. Mutations in human XPD (also known as ERCC2) mainly cause three clinical phenotypes: xeroderma pigmentosum (XP), Cockayne syndrome (XP/CS) and trichothiodystrophy (TTD), and only XP patients have a high predisposition to developin...

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Bibliographic Details
Main Authors: Karin Stettler, Xiaoming Li, Björn Sandrock, Sophie Braga-Lagache, Manfred Heller, Lutz Dümbgen, Beat Suter
Format: Article
Language:English
Published: The Company of Biologists 2015-01-01
Series:Disease Models & Mechanisms
Subjects:
Xeroderma pigmentosum
Cell cycle synchronization
Xpd
Mitotic defect
Online Access:http://dmm.biologists.org/content/8/1/81

Internet

http://dmm.biologists.org/content/8/1/81

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