A soluble form of human nectin-2 impairs exocrine secretion of pancreas and formation of zymogen granules in transgenic mice

A soluble form of human nectin-2 impairs exocrine secretion of pancreas and formation of zymogen granules in transgenic mice

Transgenic mouse lines expressing a soluble form of human nectin-2 (hNectin-2Ig Tg) exhibited distinctive elevation of amylase and lipase levels in the sera. In this study, we aimed to clarify the histopathology and to propose the transgenic mouse lines as new animal model for characteristic pancrea...

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Bibliographic Details
Main Authors: Yukiko Tomioka, Yoshikazu Fujimoto, Kanji Nakai, Kinuyo Ozaki, Sayo Yamamoto, Haruka Suyama, Masami Morimatsu, Toshihiro Ito, Etsuro Ono
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Soluble nectin-2
Pancreas
Exocrine abnormality
Endoplasmic reticulum
Transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S240558081500151X

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http://www.sciencedirect.com/science/article/pii/S240558081500151X

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