Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as pancreatic islets. Here, we investigated contributions of regulatory programs active during pancreatic development to T2D risk. Generation of chromatin maps from developmenta...

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Bibliographic Details
Main Authors: Ryan J Geusz, Allen Wang, Joshua Chiou, Joseph J Lancman, Nichole Wetton, Samy Kefalopoulou, Jinzhao Wang, Yunjiang Qiu, Jian Yan, Anthony Aylward, Bing Ren, P Duc Si Dong, Kyle J Gaulton, Maike Sander
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
Zebrafish
pancreas
hESC
chromatin
Type 2 diabetes
GWAS
Online Access:https://elifesciences.org/articles/59067

Internet

https://elifesciences.org/articles/59067

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