Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart

Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart

Dopa decarboxylase (DDC) synthesizes serotonin in the developing mouse heart where it is encoded by Ddc_exon1a, a tissue-specific paternally expressed imprinted gene. Ddc_exon1a shares an imprinting control region (ICR) with the imprinted, maternally expressed (outside of the central nervous system)...

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Bibliographic Details
Main Authors: Adam R. Prickett, Bertille Montibus, Nikolaos Barkas, Samuele M. Amante, Maurício M. Franco, Michael Cowley, William Puszyk, Matthew F. Shannon, Melita D. Irving, Marta Madon-Simon, Andrew Ward, Reiner Schulz, H. Scott Baldwin, Rebecca J. Oakey
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
dopa decarboxylase
knock-out
imprinting
heart
mouse
human
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.676543/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.676543/full

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