PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts

PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts

Abstract Background PARP inhibitors niraparib and talazoparib are FDA approved for special cases of breast cancer. PARP is an interesting repair protein which is frequently affected in cancer cells. We studied the combined action of talazoparib or niraparib with ionizing radiation in melanoma cells...

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Bibliographic Details
Main Authors: Verena Weigert, Tina Jost, Markus Hecht, Ilka Knippertz, Lucie Heinzerling, Rainer Fietkau, Luitpold V. Distel
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Cancer
Subjects:
Kinase inhibitor
Ionizing radiation
PARP1/PARP2
Cell death
Cell cycle
Homologous recombination
Online Access:http://link.springer.com/article/10.1186/s12885-020-07190-9

Internet

http://link.springer.com/article/10.1186/s12885-020-07190-9

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