Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility.

Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It is well established that various neuropsychiatric disorders (schizophrenia, autism, etc.), trinucleotide expansion associated diseases (myotonic dystrophy, Huntington's, etc.) and even some forms of c...

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Bibliographic Details
Main Authors: Timothy G Jenkins, Kenneth I Aston, Christian Pflueger, Bradley R Cairns, Douglas T Carrell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4091790?pdf=render