Thymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in mice.

Thymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in mice.

Mammal adipose tissues require mitochondrial activity for proper development and differentiation. The components of the mitochondrial respiratory chain/oxidative phosphorylation system (OXPHOS) are encoded by both mitochondrial and nuclear genomes. The maintenance of mitochondrial DNA (mtDNA) is a k...

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Bibliographic Details
Main Authors: Joan Villarroya, Beatriz Dorado, Maya R Vilà, Elena Garcia-Arumí, Pere Domingo, Marta Giralt, Michio Hirano, Francesc Villarroya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3246498?pdf=render

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http://europepmc.org/articles/PMC3246498?pdf=render

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