Revisiting the Logan plot to account for non-negligible blood volume in brain tissue

Revisiting the Logan plot to account for non-negligible blood volume in brain tissue

Abstract Background Reference tissue-based quantification of brain PET data does not typically include correction for signal originating from blood vessels, which is known to result in biased outcome measures. The bias extent depends on the amount of radioactivity in the blood vessels. In this study...

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Bibliographic Details
Main Authors: Martin Schain, Patrik Fazio, Ladislav Mrzljak, Nahid Amini, Nabil Al-Tawil, Cheryl Fitzer-Attas, Juliana Bronzova, Bernhard Landwehrmeyer, Christina Sampaio, Christer Halldin, Andrea Varrone
Format: Article
Language:English
Published: SpringerOpen 2017-08-01
Series:EJNMMI Research
Subjects:
PET
Kinetic modeling
Logan plot
[18F]MNI-659
Blood volume
PDE10A
Online Access:http://link.springer.com/article/10.1186/s13550-017-0314-z

Internet

http://link.springer.com/article/10.1186/s13550-017-0314-z

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