Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex.

Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex.

Integration of the HIV-1 cDNA into the human genome is catalyzed by the viral integrase (IN) protein. Several studies have shown the importance of cellular cofactors that interact with integrase and affect viral integration and infectivity. In this study, we produced a stable complex between HIV-1 i...

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Bibliographic Details
Main Authors: Benoit Maillot, Nicolas Lévy, Sylvia Eiler, Corinne Crucifix, Florence Granger, Ludovic Richert, Pascal Didier, Julien Godet, Karine Pradeau-Aubreton, Stéphane Emiliani, Alexis Nazabal, Paul Lesbats, Vincent Parissi, Yves Mely, Dino Moras, Patrick Schultz, Marc Ruff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3623958?pdf=render

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http://europepmc.org/articles/PMC3623958?pdf=render

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