Decidualisation and placentation defects are a major cause of age-related reproductive decline

Decidualisation and placentation defects are a major cause of age-related reproductive decline

Advanced maternal age has been associated with lower reproductive success and higher risk of pregnancy complications. Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caused by decidualisation and placentation defects that can be rescued by transferring the emb...

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Main Authors: Laura Woods, Vicente Perez-Garcia, Jens Kieckbusch, Xiaoqiu Wang, Francesco DeMayo, Francesco Colucci, Myriam Hemberger
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00308-x
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spelling doaj-ae4829e2c1f4498cb0b96e9439f9ed862021-05-11T07:21:42ZengNature Publishing GroupNature Communications2041-17232017-09-018111510.1038/s41467-017-00308-xDecidualisation and placentation defects are a major cause of age-related reproductive declineLaura Woods0Vicente Perez-Garcia1Jens Kieckbusch2Xiaoqiu Wang3Francesco DeMayo4Francesco Colucci5Myriam Hemberger6Epigenetics Programme, The Babraham Institute, Babraham Research CampusEpigenetics Programme, The Babraham Institute, Babraham Research CampusDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke’s HospitalReproductive and Developmental Biology Laboratory, NIEHSReproductive and Developmental Biology Laboratory, NIEHSDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke’s HospitalEpigenetics Programme, The Babraham Institute, Babraham Research CampusAdvanced maternal age has been associated with lower reproductive success and higher risk of pregnancy complications. Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caused by decidualisation and placentation defects that can be rescued by transferring the embryo from an old to a young uterus.https://doi.org/10.1038/s41467-017-00308-x
collection DOAJ
language English
format Article
sources DOAJ
author Laura Woods
Vicente Perez-Garcia
Jens Kieckbusch
Xiaoqiu Wang
Francesco DeMayo
Francesco Colucci
Myriam Hemberger
spellingShingle Laura Woods
Vicente Perez-Garcia
Jens Kieckbusch
Xiaoqiu Wang
Francesco DeMayo
Francesco Colucci
Myriam Hemberger
Decidualisation and placentation defects are a major cause of age-related reproductive decline
Nature Communications
author_facet Laura Woods
Vicente Perez-Garcia
Jens Kieckbusch
Xiaoqiu Wang
Francesco DeMayo
Francesco Colucci
Myriam Hemberger
author_sort Laura Woods
title Decidualisation and placentation defects are a major cause of age-related reproductive decline
title_short Decidualisation and placentation defects are a major cause of age-related reproductive decline
title_full Decidualisation and placentation defects are a major cause of age-related reproductive decline
title_fullStr Decidualisation and placentation defects are a major cause of age-related reproductive decline
title_full_unstemmed Decidualisation and placentation defects are a major cause of age-related reproductive decline
title_sort decidualisation and placentation defects are a major cause of age-related reproductive decline
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-09-01
description Advanced maternal age has been associated with lower reproductive success and higher risk of pregnancy complications. Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caused by decidualisation and placentation defects that can be rescued by transferring the embryo from an old to a young uterus.
url https://doi.org/10.1038/s41467-017-00308-x
work_keys_str_mv AT laurawoods decidualisationandplacentationdefectsareamajorcauseofagerelatedreproductivedecline
AT vicenteperezgarcia decidualisationandplacentationdefectsareamajorcauseofagerelatedreproductivedecline
AT jenskieckbusch decidualisationandplacentationdefectsareamajorcauseofagerelatedreproductivedecline
AT xiaoqiuwang decidualisationandplacentationdefectsareamajorcauseofagerelatedreproductivedecline
AT francescodemayo decidualisationandplacentationdefectsareamajorcauseofagerelatedreproductivedecline
AT francescocolucci decidualisationandplacentationdefectsareamajorcauseofagerelatedreproductivedecline
AT myriamhemberger decidualisationandplacentationdefectsareamajorcauseofagerelatedreproductivedecline
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