Decidualisation and placentation defects are a major cause of age-related reproductive decline
Advanced maternal age has been associated with lower reproductive success and higher risk of pregnancy complications. Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caused by decidualisation and placentation defects that can be rescued by transferring the emb...
Main Authors: | Laura Woods, Vicente Perez-Garcia, Jens Kieckbusch, Xiaoqiu Wang, Francesco DeMayo, Francesco Colucci, Myriam Hemberger |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-00308-x |
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