A Lung Organotypic Coculture Reveals a Role for TFEB-Lysosomal Axis in the Survival of Disseminated Dormant Cancer Cells

A Lung Organotypic Coculture Reveals a Role for TFEB-Lysosomal Axis in the Survival of Disseminated Dormant Cancer Cells

(1) Background: metastatic relapse following a prolonged period of disease-free survival is a common cause of mortality for many cancer patients. Disseminated dormant cancer cells (DDCCs) lie below the radar before waking up years, or even decades, after the removal of the primary tumor. This implie...

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Bibliographic Details
Main Authors: Manuela Zangrossi, Probir Chakravarty, Patrizia Romani, Sirio Dupont, Steven Hooper, Erik Sahai, Marco Montagner
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
dormancy
tumor microenvironment
lysosomes
TFEB
in vitro models
organotypic systems
Online Access:https://www.mdpi.com/2072-6694/13/5/1007

Internet

https://www.mdpi.com/2072-6694/13/5/1007

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