A Nanoparticle-Poly(I:C) Combination Adjuvant Enhances the Breadth of the Immune Response to Inactivated Influenza Virus Vaccine in Pigs

A Nanoparticle-Poly(I:C) Combination Adjuvant Enhances the Breadth of the Immune Response to Inactivated Influenza Virus Vaccine in Pigs

Intranasal vaccination elicits secretory IgA (SIgA) antibodies in the airways, which is required for cross-protection against influenza. To enhance the breadth of immunity induced by a killed swine influenza virus antigen (KAg) or conserved T cell and B cell peptides, we adsorbed the antigens togeth...

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Bibliographic Details
Main Authors: Sankar Renu, Ninoshkaly Feliciano-Ruiz, Fangjia Lu, Shristi Ghimire, Yi Han, Jennifer Schrock, Santosh Dhakal, Veerupaxagouda Patil, Steven Krakowka, Harm HogenEsch, Gourapura J. Renukaradhya
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Vaccines
Subjects:
Nano-11
swine influenza virus
T and B cell peptides
poly(I:C)
intranasal vaccination
mucosal immunity
Online Access:https://www.mdpi.com/2076-393X/8/2/229

Internet

https://www.mdpi.com/2076-393X/8/2/229

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