Adipocyte Fatty Acid-Binding Protein Promotes Palmitate-Induced Mitochondrial Dysfunction and Apoptosis in Macrophages

Adipocyte Fatty Acid-Binding Protein Promotes Palmitate-Induced Mitochondrial Dysfunction and Apoptosis in Macrophages

A high level of circulating free fatty acids (FFAs) is known to be an important trigger for macrophage apoptosis during the development of atherosclerosis. However, the underlying mechanism by which FFAs result in macrophage apoptosis is not well understood. In cultured human macrophage Thp-1 cells,...

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Bibliographic Details
Main Authors: Hui Li, Yang Xiao, Lin Tang, Feng Zhong, Gan Huang, Jun-Mei Xu, Ai-Min Xu, Ru-Ping Dai, Zhi-Guang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
adipocyte fatty acid-binding protein
mitochondrial dysfunction
apoptosis
macrophage
palmitate
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00081/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00081/full

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