Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy.

Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy.

Adoptive T cell therapy (ACT) has become a treatment option for viral reactivations in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). Animal models have shown that pathogen-specific central memory T cells (TCM) are protective even at low numbers and show long-term...

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Bibliographic Details
Main Authors: Benjamin Faist, Fabian Schlott, Christian Stemberger, Kevin M Dennehy, Angela Krackhardt, Mareike Verbeek, Götz U Grigoleit, Matthias Schiemann, Dieter Hoffmann, Andrea Dick, Klaus Martin, Martin Hildebrandt, Dirk H Busch, Michael Neuenhahn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0223258

Internet

https://doi.org/10.1371/journal.pone.0223258

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