Modulation of the Endothelin System in Colorectal Cancer Liver Metastasis: Influence of Epigenetic Mechanisms?

Modulation of the Endothelin System in Colorectal Cancer Liver Metastasis: Influence of Epigenetic Mechanisms?

Targeting of endothelin system genes is a promising strategy in cancer therapy. The modulation of these genes was explored in a model of colorectal cancer (CRC) liver metastasis and in a panel of CRC tumor cell lines that were exposed to the demethylating agent decitabine. The CC531 rat model mimick...

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Bibliographic Details
Main Authors: Mohamed R. Mahdi, Rania B. Georges, Doaa M. Ali, Raouf F. Bedeer, Huda M. Eltahry, Abd-El Hakiem Z. Gabr, Martin R. Berger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
endothelin system
DNA methyltransferase
decitabine
epigenetic mechanism
colorectal cancer cell lines
liver metastasis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00180/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00180/full

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