An ARHGAP25 variant links aberrant Rac1 function to early‐onset skeletal fragility

An ARHGAP25 variant links aberrant Rac1 function to early‐onset skeletal fragility

ABSTRACT Ras homologous guanosine triphosphatases (RhoGTPases) control several cellular functions, including cytoskeletal actin remodeling and cell migration. Their activities are downregulated by GTPase‐activating proteins (GAPs). Although RhoGTPases are implicated in bone remodeling and osteoclast...

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Bibliographic Details
Main Authors: Riikka E. Mäkitie, Petra Henning, Yaming Jiu, Anders Kämpe, Konstantin Kogan, Alice Costantini, Ville‐Valtteri Välimäki, Carolina Medina‐Gomez, Minna Pekkinen, Isidro B. Salusky, Camilla Schalin‐Jäntti, Maria K. Haanpää, Fernando Rivadeneira, John H. Duncan Bassett, Graham R. Williams, Ulf H. Lerner, Renata C. Pereira, Pekka Lappalainen, Outi Mäkitie
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:JBMR Plus
Subjects:
OSTEOGENESIS IMPERFECTA
OSTEOPOROSIS
BONE MODELING AND REMODELING
CELL/TISSUE SIGNALING ‐ OTHER
GENETIC RESEARCH
Online Access:https://doi.org/10.1002/jbm4.10509

Internet

https://doi.org/10.1002/jbm4.10509

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