Structural mapping of oligomeric intermediates in an amyloid assembly pathway

Structural mapping of oligomeric intermediates in an amyloid assembly pathway

Transient oligomers are commonly formed in the early stages of amyloid assembly. Determining the structure(s) of these species and defining their role(s) in assembly is key to devising new routes to control disease. Here, using a combination of chemical kinetics, NMR spectroscopy and other biophysic...

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Bibliographic Details
Main Authors: Theodoros K Karamanos, Matthew P Jackson, Antonio N Calabrese, Sophia C Goodchild, Emma E Cawood, Gary S Thompson, Arnout P Kalverda, Eric W Hewitt, Sheena E Radford
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
amyloid
oligomer
aggregation
NMR
microglobulin
Online Access:https://elifesciences.org/articles/46574

Internet

https://elifesciences.org/articles/46574

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