A Deep-Learning Sequence-Based Method to Predict Protein Stability Changes Upon Genetic Variations

Several studies have linked disruptions of protein stability and its normal functions to disease. Therefore, during the last few decades, many tools have been developed to predict the free energy changes upon protein residue variations. Most of these methods require both sequence and structure infor...

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Bibliographic Details
Main Authors: Corrado Pancotti, Silvia Benevenuta, Valeria Repetto, Giovanni Birolo, Emidio Capriotti, Tiziana Sanavia, Piero Fariselli
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/12/6/911