Imatinib treatment reduces brain injury in a murine model of traumatic brain injury

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury

Current therapies for Traumatic brain injury (TBI) focus on stabilizing individuals and on preventing further damage from the secondary consequences of TBI. A major complication of TBI is cerebral edema, which can be caused by the loss of blood brain barrier (BBB) integrity. Recent studies in severa...

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Bibliographic Details
Main Authors: Enming Joe Su, Linda eFredriksson, Mia eKanzawa, Shannon eMoore, Erika eFolestad, Tamara K Stevenson, Ingrid eNilsson, Maithili eSashindranath, Gerald P Schielke, Mark eWarnock, Margaret eRagsdale, Kris eMann, Anna-Lisa E Lawrence, Robert Lindsay Medcalf, Ulf eEriksson, Geoffrey G Murphy, Daniel A Lawrence
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Traumatic Brain Injury
blood brain barrier
cerebral edema
Imatinib
Morris water maze
TBI outcome
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00385/full

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http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00385/full

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