Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer

Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer

Abstract Background Epigenetics has been known to play a critical role in regulating the malignant phenotype. This study was designed to examine the expression of DOT1L (histone 3 lysine 79 methyltransferase) and H3K79 methylation in normal ovarian tissues and ovarian tumors and to explore the funct...

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Bibliographic Details
Main Authors: Xiaoxue Zhang, Dan Liu, Mengchen Li, Canhui Cao, Dongyi Wan, Bixin Xi, Wenqian Li, Jiahong Tan, Ji Wang, Zhongcai Wu, Ding Ma, Qinglei Gao
Format: Article
Language:English
Published: BMC 2017-01-01
Series:Journal of Hematology & Oncology
Subjects:
DOT1L
Ovarian cancer
Prognosis
ChIP-seq
G1 arrest
Online Access:http://link.springer.com/article/10.1186/s13045-017-0400-8

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http://link.springer.com/article/10.1186/s13045-017-0400-8

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