Repeated administration of the noradrenergic neurotoxin <it>N-</it>(2-chloroethyl)-<it>N</it>-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

Repeated administration of the noradrenergic neurotoxin <it>N-</it>(2-chloroethyl)-<it>N</it>-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

<p>Abstract</p> <p>Background</p> <p>Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus...

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Bibliographic Details
Main Authors: Richardson Jill C, Virley David J, Babin Anna, Bate Simon T, Joyce Flora, Perren Marion J, Seymour Zoe, Culbert Ainsley A, Ashmeade Tracey, Vidgeon-Hart Martin P, Pugh Perdita L, Upton Neil, Sunter David
Format: Article
Language:English
Published: BMC 2007-02-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/4/1/8

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http://www.jneuroinflammation.com/content/4/1/8

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