Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

The attachment of biotin to a small molecule provides a powerful tool in biology. Here, we present a systematic approach to identify biotinylated analogues of the Hsp90 inhibitor PU-H71 that are capable of permeating cell membranes so as to enable the investigation of Hsp90 complexes in live cells....

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Bibliographic Details
Main Authors: Tony Taldone, Anna Rodina, Erica M. DaGama Gomes, Matthew Riolo, Hardik J. Patel, Raul Alonso-Sabadell, Danuta Zatorska, Maulik R. Patel, Sarah Kishinevsky, Gabriela Chiosis
Format: Article
Language:English
Published: Beilstein-Institut 2013-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
affinity capture
biotin
flow cytometry
fluorescence microscopy
PU-H71
tumor Hsp90
Online Access:https://doi.org/10.3762/bjoc.9.60

Internet

https://doi.org/10.3762/bjoc.9.60

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