Stromal Features of the Primary Tumor Are Not Prognostic in Genetically Engineered Mice of Pancreatic Cancer

Stromal Features of the Primary Tumor Are Not Prognostic in Genetically Engineered Mice of Pancreatic Cancer

The Kras<sup>G12D/+</sup>;LSL-Trp53<sup>R172H/+</sup>;Pdx-1-Cre (KPC) mouse model is frequently employed for preclinical therapeutic testing, in particular in regard to antistromal therapies. Here, we investigate the prognostic implications of histopathological features that...

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Bibliographic Details
Main Authors: Marie C. Hasselluhn, Lukas Klein, Melanie S. Patzak, Sören M. Buchholz, Philipp Ströbel, Volker Ellenrieder, Patrick Maisonneuve, Albrecht Neesse
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cells
Subjects:
pancreatic cancer
tumor microenvironment
cancer-associated fibroblasts
activated stroma index
kpc model
Online Access:https://www.mdpi.com/2073-4409/9/1/58

Internet

https://www.mdpi.com/2073-4409/9/1/58

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