Simultaneous quantification of nimesulide, phenylpropanolamine, caffeine and chlorpheniramine in rat plasma by RP–HPLC/PDA method and application to pharmacokinetic studies in healthy rat subjects
Simultaneous determination of nimesulide, phenylpropanolamine, chlorpheniramine and caffeine in rat plasma by reversed-phase high performance liquid-chromatography (RP–HPLC) with photodiode array (PDA) detection method was developed and validated. Sample preparation based on a simple extraction proc...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-12-01
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Series: | Arabian Journal of Chemistry |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535215000295 |