Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

Abstract Background Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endothelial glycocalyx, a heparan sulfate-enriched structure necessary for va...

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Bibliographic Details
Main Authors: Joseph A. Hippensteel, Ryo Uchimido, Patrick D. Tyler, Ryan C. Burke, Xiaorui Han, Fuming Zhang, Sarah A. McMurtry, James F. Colbert, Christopher J. Lindsell, Derek C. Angus, John A. Kellum, Donald M. Yealy, Robert J. Linhardt, Nathan I. Shapiro, Eric P. Schmidt
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Critical Care
Subjects:
Sepsis
Multiple organ failure
Endothelial glycocalyx
Fluid resuscitation
Online Access:http://link.springer.com/article/10.1186/s13054-019-2534-2

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http://link.springer.com/article/10.1186/s13054-019-2534-2

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