Low-Intensity MR-Guided Focused Ultrasound Mediated Disruption of the Blood-Brain Barrier for Intracranial Metastatic Diseases
Low-intensity MR-guided focused ultrasound in combination with intravenously injected microbubbles is a promising platform for drug delivery to the central nervous system past the blood-brain barrier. The blood-brain barrier is a key bottleneck for cancer therapeutics via limited inter- and intracel...
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2018-08-01
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doaj-ae7c3e8ab6084e069a95e431babad8f32020-11-25T02:36:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-08-01810.3389/fonc.2018.00338409829Low-Intensity MR-Guided Focused Ultrasound Mediated Disruption of the Blood-Brain Barrier for Intracranial Metastatic DiseasesYing Meng0Ying Meng1Suganth Suppiah2Shanan Surendrakumar3Luca Bigioni4Nir Lipsman5Nir Lipsman6Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, CanadaHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, CanadaDivision of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, CanadaHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, CanadaHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, CanadaDivision of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, CanadaHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, CanadaLow-intensity MR-guided focused ultrasound in combination with intravenously injected microbubbles is a promising platform for drug delivery to the central nervous system past the blood-brain barrier. The blood-brain barrier is a key bottleneck for cancer therapeutics via limited inter- and intracellular transport. Further, drugs that cross the blood-brain barrier when delivered in a spatially nonspecific way, result in adverse effects on normal brain tissue, or at high concentrations, result in increasing risks to peripheral organs. As such, various anti-cancer drugs that have been developed or to be developed in the future would benefit from a noninvasive, temporary, and repeatable method of targeted opening of the blood-brain barrier to treat metastatic brain diseases. MR-guided focused ultrasound is a potential solution to these design requirements. The safety, feasibility and preliminary efficacy of MRgFUS aided delivery have been demonstrated in various animal models. In this review, we discuss this preclinical evidence, mechanisms of focused ultrasound mediated blood-brain barrier opening, and translational efforts to neuro-oncology patients.https://www.frontiersin.org/article/10.3389/fonc.2018.00338/fullfocused ultrasound (MRgFUS)blood brain barrier (BBB) disruptionneuro-oncology–surgicalintracranial metastatic diseasedrug deliver-system |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Meng Ying Meng Suganth Suppiah Shanan Surendrakumar Luca Bigioni Nir Lipsman Nir Lipsman |
spellingShingle |
Ying Meng Ying Meng Suganth Suppiah Shanan Surendrakumar Luca Bigioni Nir Lipsman Nir Lipsman Low-Intensity MR-Guided Focused Ultrasound Mediated Disruption of the Blood-Brain Barrier for Intracranial Metastatic Diseases Frontiers in Oncology focused ultrasound (MRgFUS) blood brain barrier (BBB) disruption neuro-oncology–surgical intracranial metastatic disease drug deliver-system |
author_facet |
Ying Meng Ying Meng Suganth Suppiah Shanan Surendrakumar Luca Bigioni Nir Lipsman Nir Lipsman |
author_sort |
Ying Meng |
title |
Low-Intensity MR-Guided Focused Ultrasound Mediated Disruption of the Blood-Brain Barrier for Intracranial Metastatic Diseases |
title_short |
Low-Intensity MR-Guided Focused Ultrasound Mediated Disruption of the Blood-Brain Barrier for Intracranial Metastatic Diseases |
title_full |
Low-Intensity MR-Guided Focused Ultrasound Mediated Disruption of the Blood-Brain Barrier for Intracranial Metastatic Diseases |
title_fullStr |
Low-Intensity MR-Guided Focused Ultrasound Mediated Disruption of the Blood-Brain Barrier for Intracranial Metastatic Diseases |
title_full_unstemmed |
Low-Intensity MR-Guided Focused Ultrasound Mediated Disruption of the Blood-Brain Barrier for Intracranial Metastatic Diseases |
title_sort |
low-intensity mr-guided focused ultrasound mediated disruption of the blood-brain barrier for intracranial metastatic diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2018-08-01 |
description |
Low-intensity MR-guided focused ultrasound in combination with intravenously injected microbubbles is a promising platform for drug delivery to the central nervous system past the blood-brain barrier. The blood-brain barrier is a key bottleneck for cancer therapeutics via limited inter- and intracellular transport. Further, drugs that cross the blood-brain barrier when delivered in a spatially nonspecific way, result in adverse effects on normal brain tissue, or at high concentrations, result in increasing risks to peripheral organs. As such, various anti-cancer drugs that have been developed or to be developed in the future would benefit from a noninvasive, temporary, and repeatable method of targeted opening of the blood-brain barrier to treat metastatic brain diseases. MR-guided focused ultrasound is a potential solution to these design requirements. The safety, feasibility and preliminary efficacy of MRgFUS aided delivery have been demonstrated in various animal models. In this review, we discuss this preclinical evidence, mechanisms of focused ultrasound mediated blood-brain barrier opening, and translational efforts to neuro-oncology patients. |
topic |
focused ultrasound (MRgFUS) blood brain barrier (BBB) disruption neuro-oncology–surgical intracranial metastatic disease drug deliver-system |
url |
https://www.frontiersin.org/article/10.3389/fonc.2018.00338/full |
work_keys_str_mv |
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