4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice

4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice

Acetaminophen (APAP) overdose is the principal cause of drug-induced acute liver failure. 4-hydroxyphenylacetic acid (4-HPA), a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. This study seeks to investigate the ability of 4-HPA to protect against APAP-in...

Full description

Bibliographic Details
Main Authors: Hongqiong Zhao, Zhihui Jiang, Xuemei Chang, Huiting Xue, Wumaierjiang Yahefu, Xiaoying Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
polyphenols
4-hydroxyphenylacetic acid 4-HPA
acetaminophen APAP
hepatotoxicity
oxidative stress
nuclear factor erythroid 2-related factor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00653/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00653/full

Similar Items