High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice

Abstract Maternal folic acid (FA) supplementation prior to and during gestation is recommended for the prevention of neural tube closure defects in the developing embryo. Prior studies, however, suggested that excessive FA supplementation during gestation can be associated with toxic effects on the...

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Bibliographic Details
Main Authors: Kristin S. Henzel, Devon P. Ryan, Susanne Schröder, Marco Weiergräber, Dan Ehninger
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03158-1