Comparison of methacholine and mannitol challenges: importance of method of methacholine inhalation

Abstract Background Direct inhalation challenges (e.g. methacholine) are stated to be more sensitive and less specific for a diagnosis of asthma than are indirect challenges (e.g. exercise, non-isotonic aerosols, mannitol, etc.). However, data surrounding comparative sensitivity and specificity for...

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Bibliographic Details
Main Authors: Donald W. Cockcroft, Beth E. Davis, Christianne M. Blais
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Allergy, Asthma & Clinical Immunology
Subjects:
Online Access:https://doi.org/10.1186/s13223-020-0410-x