The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication

The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication

Fluoroquinolones have been extremely successful antibiotics due to their ability to target multiple bacterial enzymes critical to DNA replication, the topoisomerases DNA gyrase and topo IV. Unfortunately, mutations lowering drug affinity for both enzymes are now widespread, rendering these drugs ine...

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Bibliographic Details
Main Authors: Edward Geisinger, Germán Vargas-Cuebas, Nadav J. Mortman, Sapna Syal, Yunfei Dai, Elizabeth L. Wainwright, David Lazinski, Stephen Wood, Zeyu Zhu, Jon Anthony, Tim van Opijnen, Ralph R. Isberg
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
Acinetobacter
DNA gyrase
fitness
fluoroquinolone
prophage
antibiotic resistance
ciprofloxacin
topoisomerase IV
Online Access:https://doi.org/10.1128/mBio.01127-19

Internet

https://doi.org/10.1128/mBio.01127-19

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