The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication
Fluoroquinolones have been extremely successful antibiotics due to their ability to target multiple bacterial enzymes critical to DNA replication, the topoisomerases DNA gyrase and topo IV. Unfortunately, mutations lowering drug affinity for both enzymes are now widespread, rendering these drugs ine...
Main Authors: | Edward Geisinger, Germán Vargas-Cuebas, Nadav J. Mortman, Sapna Syal, Yunfei Dai, Elizabeth L. Wainwright, David Lazinski, Stephen Wood, Zeyu Zhu, Jon Anthony, Tim van Opijnen, Ralph R. Isberg |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2019-06-01
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Series: | mBio |
Subjects: | |
Online Access: | https://doi.org/10.1128/mBio.01127-19 |
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