DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

Cholesterol and docosahexenoic acid (DHA) may affect degenerative processes in Alzheimer's Disease (AD) by influencing Aβ metabolism indirectly via the vasculature. We investigated whether DHA-enriched diets or cholesterol-containing Typical Western Diets (TWD) alter behavior and cognition, cer...

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Bibliographic Details
Main Authors: C.R. Hooijmans, C.E.E.M. Van der Zee, P.J. Dederen, K.M. Brouwer, Y.D. Reijmer, T. van Groen, L.M. Broersen, D. Lütjohann, A. Heerschap, A.J. Kiliaan
Format: Article
Language:English
Published: Elsevier 2009-03-01
Series:Neurobiology of Disease
Subjects:
APPswe/PS1dE9 transgenic mice
MRI
Cerebral blood volume
Alzheimer's Disease
Amyloid-β
Cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108003070

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http://www.sciencedirect.com/science/article/pii/S0969996108003070

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