Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection

We have previously developed a robust regimen for tolerance induction in murine models of islet cell transplantation using pre- and posttransplant infusions of donor splenocytes (SPs) treated with a chemical cross-linker ethylcarbodiimide (ECDI). However, the requirement for large numbers of fresh d...

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Bibliographic Details
Main Authors: Shusen Wang, Xiaomin Zhang, Lei Zhang, Jane Bryant, Taba Kheradmand, Bernhard J. Hering, Stephen D. Miller, Xunrong Luo M.D., Ph.D.
Format: Article
Language:English
Published: SAGE Publishing 2015-06-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368914X681027