Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein

Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein

Therapeutic agents that suppress apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) levels/activity are being developed in the clinic to benefit patients who are unable to reach target LDL-C levels with maximally tolerated lipid-lowering drugs. To compare and contrast the met...

Full description

Bibliographic Details
Main Authors: Richard G. Lee, Wuxia Fu, Mark J. Graham, Adam E. Mullick, Donna Sipe, Danielle Gattis, Thomas A. Bell, Sheri Booten, Rosanne M. Crooke
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Journal of Lipid Research
Subjects:
microsomal triglyceride transfer protein
dyslipidemia
steatosis
lipoprotein metabolism
lipid droplets
familial hypercholesterolemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520419261

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520419261

Similar Items