Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations

Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations

Eukaryotic initiation factor 5A (eIF5A) is a conserved protein with an essential role in translation elongation. Using one and two-dimensional western blotting, we showed that the eIF5A protein level was 2-fold lower in benznidazole (BZ)-resistant (BZR and 17LER) Trypanosoma cruzi populations than i...

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Bibliographic Details
Main Authors: Douglas de Souza Moreira, Ana Paula Duarte, Fabiano Sviatopolk Mirsky Pais, Rosiane Aparecida da Silva-Pereira, Alvaro José Romanha, Sergio Schenkman, Silvane Maria Fonseca Murta
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2018-07-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Trypanosoma cruzi
drug resistance
benznidazole
eukaryotic initiation factor 5A (eIF5A)
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000900400&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000900400&lng=en&tlng=en

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