Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons

Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons

Dendrite aberration is a common feature of neurodegenerative diseases caused by protein toxicity, but the underlying mechanisms remain largely elusive. Here, we show that nuclear polyglutamine (polyQ) toxicity resulted in defective terminal dendrite elongation accompanied by a loss of Golgi outposts...

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Bibliographic Details
Main Authors: Chang Geon Chung, Min Jee Kwon, Keun Hye Jeon, Do Young Hyeon, Myeong Hoon Han, Jeong Hyang Park, In Jun Cha, Jae Ho Cho, Kunhyung Kim, Sangchul Rho, Gyu Ree Kim, Hyobin Jeong, Jae Won Lee, TaeSoo Kim, Keetae Kim, Kwang Pyo Kim, Michael D. Ehlers, Daehee Hwang, Sung Bae Lee
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
polyQ
Golgi outposts
CrebA
CREB3L1
CBP
dendrites
neurodegeneration
ataxin-3
nuclear proteotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308902

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http://www.sciencedirect.com/science/article/pii/S2211124717308902

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