Ratatosk: hybrid error correction of long reads enables accurate variant calling and assembly
Abstract A major challenge to long read sequencing data is their high error rate of up to 15%. We present Ratatosk, a method to correct long reads with short read data. We demonstrate on 5 human genome trios that Ratatosk reduces the error rate of long reads 6-fold on average with a median error rat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-01-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-020-02244-4 |