Biological and clinical significance of cancer stem cell plasticity

Abstract In the past decade, the traditional view of cancers as a homogeneous collection of malignant cells is being replaced by a model of ever increasing complexity suggesting that cancers are complex tissues composed of multiple cell types. This complex model of tumorigenesis has been well suppor...

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Bibliographic Details
Main Authors: Yongyou Zhu, Ming Luo, Michael Brooks, Shawn G Clouthier, Max S Wicha
Format: Article
Language:English
Published: Wiley 2014-12-01
Series:Clinical and Translational Medicine
Subjects:
MET
EMT
Online Access:https://doi.org/10.1186/s40169-014-0032-3