Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders

Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders

Genistein has been reported to have antioxidant and neuroprotective activity. Despite encouraging in vitro and in vivo results, several disadvantages such as poor water solubility, rapid metabolism, and low oral bioavailability limit the clinical application of genistein. The aim of this study was t...

Full description

Bibliographic Details
Main Authors: Giovanna Rassu, Elena Piera Porcu, Silvia Fancello, Antonella Obinu, Nina Senes, Grazia Galleri, Rossana Migheli, Elisabetta Gavini, Paolo Giunchedi
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Pharmaceutics
Subjects:
chitosan
genistein
sodium hexametaphosphate
nose-to-brain
intranasal delivery
neurodegenerative disease
nanoparticles
Online Access:http://www.mdpi.com/1999-4923/11/1/8

Internet

http://www.mdpi.com/1999-4923/11/1/8

Similar Items