Dynamic response of microglia/macrophage polarization following demyelination in mice

Dynamic response of microglia/macrophage polarization following demyelination in mice

Abstract Background The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function. As a central player in neuroinflammation, activation and polarizat...

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Bibliographic Details
Main Authors: Tianci Chu, Yi Ping Zhang, Zhisen Tian, Chuyuan Ye, Mingming Zhu, Lisa B. E. Shields, Maiying Kong, Gregory N. Barnes, Christopher B. Shields, Jun Cai
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Focal demyelination model
Oligodendrocyte/oligodendrocyte progenitor cells
Microglia/macrophage
Neuroinflammation
Sensorimotor function
Online Access:http://link.springer.com/article/10.1186/s12974-019-1586-1

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http://link.springer.com/article/10.1186/s12974-019-1586-1

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