Revisiting the Coreceptor Function of Complement Receptor Type 2 (CR2, CD21); Coengagement With the B-Cell Receptor Inhibits the Activation, Proliferation, and Antibody Production of Human B Cells

Revisiting the Coreceptor Function of Complement Receptor Type 2 (CR2, CD21); Coengagement With the B-Cell Receptor Inhibits the Activation, Proliferation, and Antibody Production of Human B Cells

The positive coreceptor function of complement receptor type 2 [CR2 (CD21)] on B cells is generally accepted, although its role in the enhancement of antibody production had only been proven in mice. The importance of this phenomenon prompted reinvestigation of the functional consequences of coclust...

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Bibliographic Details
Main Authors: Kristóf G. Kovács, Bernadett Mácsik-Valent, János Matkó, Zsuzsa Bajtay, Anna Erdei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
B cell
CR2 (CD21)
coreceptor
Ca2+ response
inhibition
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.620427/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.620427/full

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