Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects(◆)(◆)This work was supported in part by National Institutes of Health grants GM 62883, GM 32165, AI52663, AI 077390, HL 56548. RJYH was also supported by Milo Gibaldi Endowment. KVK was supported in part by NIH grant DK-02957.

Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects(◆)(◆)This work was supported in part by National Institutes of Health grants GM 62883, GM 32165, AI52663, AI 077390, HL 56548. RJYH was also supported by Milo Gibaldi Endowment. KVK was supported in part by NIH grant DK-02957.

Introduction. CYP2D6 is a liver enzyme that metabolizes more that 25% of drugs and thus may play a pivotal role in drug-drug interactions. The promoter sequences of cytochrome P450 2D6 (CYP2D6) gene could impact metabolic activity.Methods. We analyzed genetic variations in the promoter sequence of C...

Full description

Bibliographic Details
Main Authors: Martin T. Ho, Edward J. Kelly, Miklos Bodor, Tot Bui, Kris V. Kowdley, Rodney J.Y. Ho, Ph.D.
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Annals of Hepatology
Subjects:
CYP450 enzyme
Genotype
Phenotype
Genetic variant
Hepatitis
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268119315455

Internet

http://www.sciencedirect.com/science/article/pii/S1665268119315455

Similar Items