Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment

Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment

Abstract Background Immuno-oncotherapy has emerged as a promising means to target cancer. In particular, therapeutic manipulation of tumor-associated macrophages holds promise due to their various and sometimes opposing roles in tumor progression. It is established that M1-type macrophages suppress...

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Bibliographic Details
Main Authors: Grace Mahlbacher, Louis T. Curtis, John Lowengrub, Hermann B. Frieboes
Format: Article
Language:English
Published: BMJ Publishing Group 2018-01-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Cancer immunotherapy
Cancer metastasis
Tumor-associated macrophages
Tie2 expressing macrophages
Mathematical modeling
Computational simulation
Online Access:http://link.springer.com/article/10.1186/s40425-017-0313-7

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http://link.springer.com/article/10.1186/s40425-017-0313-7

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