Pathophysiology of NSAID-Associated Intestinal Lesions in the Rat: Luminal Bacteria and Mucosal Inflammation as Targets for Prevention

Pathophysiology of NSAID-Associated Intestinal Lesions in the Rat: Luminal Bacteria and Mucosal Inflammation as Targets for Prevention

Non-steroidal anti-inflammatory drugs (NSAIDs) can damage the small intestine, mainly through an involvement of enteric bacteria. This study examined the pathophysiology of NSAID-associated intestinal lesions in a rat model of diclofenac-enteropathy and evaluated the effect of rifaximin on small bow...

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Bibliographic Details
Main Authors: Rocchina Colucci, Carolina Pellegrini, Matteo Fornai, Erika Tirotta, Luca Antonioli, Cecilia Renzulli, Emilia Ghelardi, Elena Piccoli, Daniela Gentile, Laura Benvenuti, Gianfranco Natale, Federica Fulceri, Pablo Palazón-Riquelme, Gloria López-Castejón, Corrado Blandizzi, Carmelo Scarpignato
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
non-steroidal anti-inflammatory drugs
intestinal damage
intestinal bleeding
rifaximin
enteroprotection
microbiota
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01340/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01340/full

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