High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability

High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability

Abstract Background Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2) is a microtubule associated protein that functions in mitotic spindle assembly. TPX2 also localizes to the nucleus where it functions in DNA damage repair during S-phase. We and others have previously shown that TPX2 RNA...

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Bibliographic Details
Main Authors: Daniel R. Matson, Ryan A. Denu, Lauren M. Zasadil, Mark E. Burkard, Beth A. Weaver, Christopher Flynn, P. Todd Stukenberg
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Cancer
Subjects:
MeSH: breast neoplasms
Chromosomal instability
Tumor suppressor protein p53
Pathology
Other: Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2).
Online Access:https://doi.org/10.1186/s12885-021-07893-7

Internet

https://doi.org/10.1186/s12885-021-07893-7

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