Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport

Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport

Summary The ubiquitin system plays an important role in trafficking of signaling receptors from the plasma membrane to lysosomes. Triad1 is a ubiquitin ligase that catalyzes the formation of poly-ubiquitin chains linked via lysine-48 as well as lysine-63 residues. We show that depletion of Triad1 af...

Full description

Bibliographic Details
Main Authors: Gerco Hassink, Johan Slotman, Viola Oorschot, Bert A. Van Der Reijden, Davide Monteferrario, Sylvie M. Noordermeer, Peter Van Kerkhof, Judith Klumperman, Ger J. Strous
Format: Article
Language:English
Published: The Company of Biologists 2012-05-01
Series:Biology Open
Subjects:
EGF
GH
Triad1
Degradation
Endosome
Membrane receptors
Online Access:http://bio.biologists.org/content/1/6/607

Internet

http://bio.biologists.org/content/1/6/607

Similar Items