Imaging-Based Subtypes of Pancreatic Ductal Adenocarcinoma Exhibit Differential Growth and Metabolic Patterns in the Pre-Diagnostic Period: Implications for Early Detection

Imaging-Based Subtypes of Pancreatic Ductal Adenocarcinoma Exhibit Differential Growth and Metabolic Patterns in the Pre-Diagnostic Period: Implications for Early Detection

BackgroundPreviously, we characterized subtypes of pancreatic ductal adenocarcinoma (PDAC) on computed-tomography (CT) scans, whereby conspicuous (high delta) PDAC tumors are more likely to have aggressive biology and poorer clinical outcomes compared to inconspicuous (low delta) tumors. Here, we hy...

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Bibliographic Details
Main Authors: Mohamed Zaid, Dalia Elganainy, Prashant Dogra, Annie Dai, Lauren Widmann, Pearl Fernandes, Zhihui Wang, Maria J. Pelaez, Javier R. Ramirez, Aatur D. Singhi, Anil K. Dasyam, Randall E. Brand, Walter G. Park, Syed Rahmanuddin, Michael H. Rosenthal, Brian M. Wolpin, Natalia Khalaf, Ajay Goel, Daniel D. Von Hoff, Eric P. Tamm, Anirban Maitra, Vittorio Cristini, Eugene J. Koay
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
early detection
computed tomography
mathematical modeling
tumor metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.596931/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.596931/full

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