A Pilot Study towards the Impact of Type 2 Diabetes on the Expression and Activities of Drug Metabolizing Enzymes and Transporters in Human Duodenum

A Pilot Study towards the Impact of Type 2 Diabetes on the Expression and Activities of Drug Metabolizing Enzymes and Transporters in Human Duodenum

To characterize effects of type 2 diabetes (T2D) on mRNA expression levels for 10 Cytochromes P450 (CYP450s), two carboxylesterases, and three drug transporters (ABCB1, ABCG2, SLCO2B1) in human duodenal biopsies. To compare drug metabolizing enzyme activities of four CYP450 isoenzymes in duodenal bi...

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Bibliographic Details
Main Authors: Sophie Gravel, Benoit Panzini, Francois Belanger, Jacques Turgeon, Veronique Michaud
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
drug metabolism
cytochromes P450
intestine
type II diabetes mellitus
Online Access:https://www.mdpi.com/1422-0067/20/13/3257

Internet

https://www.mdpi.com/1422-0067/20/13/3257

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